Equipment cleaning is fundamental to controlling particle contamination in GMP manufacturing facilities.
In aseptic environments, automated filling lines are routinely cleaned between campaigns to decontaminate product contact surfaces. As part of clean out-of-place procedures in oral dose facilities, mixing, blending, coating, dispensing, tablet presses and packaging equipment undergo extensive wiping. In Medical device facilities, the entire production process and even the device itself are cleaned via manual wiping.
In addition to bioburdens, proper equipment cleaning is vital in controlling nonviable or subvisible particles (FM) generated by the operation of the equipment. The friction-generated contamination from regular machine operation causes dark particles, which are often metallic in makeup and are a significant source of product rejects and related CAPAs.
While it is well documented that wiping is required to clean machine-generated contamination, less well understood is the number of particles that are embedded in the grain of equipment surfaces and how wiper selection can impact cleaning performance and productivity. The link below demonstrates how a cleanroom microfiber wiper can significantly improve cleaning SOP vs. standard lint-free wipers.
The link below demonstrates how a cleanroom microfiber wiper can significantly improve cleaning SOP vs. standard lint-free wipers.
How to Improve Aseptic Equipment Cleaning [Video]
The link below demonstrates how a state-of-the-art cleanroom microfiber wiper can significantly improve cleaning SOP vs. standard lint-free wipers.
How to Reduce Turn Over Times in Aseptic Processing Areas [Video]