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Improving the Productivity of Cleaning & Disinfection Procedures at CAR-T Manufacturing Sites

by | Dec 27, 2022

As the CAR-T (Chimeric Antigen Receptor T-cell) therapy market continues to grow, so does the importance of highly productive yet thorough cleaning and disinfection Standard Operating Procedures (SOPs) in CAR-T production suites. These SOPs are crucial for ensuring that the CAR-T products are safe, pure, and effective for use in patients.

The CAR-T production process involves the isolation and expansion of T-cells from a patient’s blood, modification of the T-cells with a chimeric antigen receptor, and then the re-infusion of the modified T-cells back into the patient. This process requires a clean and sterile environment to prevent contamination and ensure the safety and efficacy of the final product.

One of the main reasons for the importance of thorough cleaning and disinfection SOPs in CAR-T production suites is to prevent contamination. Contamination can occur from a variety of sources, including bacteria, fungi, and other microorganisms that can potentially harm the patient or reduce the effectiveness of the CAR-T product. Proper cleaning and disinfection can help to prevent the growth and spread of these contaminants, ensuring the safety and purity of the final product.

In addition to preventing contamination, thorough cleaning and disinfection SOPs are also essential for maintaining the efficiency and productivity of the CAR-T production process. A dirty or contaminated production suite can lead to delays and disruptions in the production process, which can impact the availability of the final product for patients. By maintaining a clean and sterile environment, the production process can run smoothly and efficiently, helping to ensure that patients have access to the life-saving CAR-T therapy when they need it.

Overall, the importance of highly productive yet thorough cleaning and disinfection SOPs in CAR-T production suites cannot be overstated. These SOPs help prevent contamination and maintain the final product’s purity, safety, and efficacy while supporting the production process’s efficiency and productivity. By following these SOPs, CAR-T production facilities can help to ensure that patients receive the highest quality CAR-T therapy possible.

To assist production managers running CAR-T facilities, Foamtec has introduced PharmaMOP GO, a hands-free cleaning and disinfection solution that is designed to enhance productivity and compliance in Good Manufacturing Practice (GMP) cleanrooms.

For more information about the PharmaMOP GO System please visit the link below:

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